Compound ID | 1967

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Brodimoprim

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Folate synthesis inhibitor. Dihydrofolate reductase inhibitor; DHFR inhibitor
Description: Synthetic compound; trimethoprim derivative; a diaminopyrimidine
Year first mentioned: 1984
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 339.19
Iso. SMILES: COC1=CC(=CC(=C1Br)OC)CC2=CN=C(N=C2N)N
InChI Key: BFCRRLMMHNLSCP-UHFFFAOYSA-N
Can. SMILES: COC1=CC(=CC(=C1Br)OC)CC2=C(N)N=C(N)N=C2
InChI: InChI=1S/C13H15BrN4O2/c1-19-9-4-7(5-10(20-2)11(9)14)3-8-6-17-13(16)18-12(8)15/h4-6H,3H2,1-2H3,(H4,15,16,17,18)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/68760
Guide to Pharmacology: brodimoprim
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/7562018/
  • https://pubmed.ncbi.nlm.nih.gov/8195838/
  • https://www.karger.com/Article/Abstract/238239

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