Epiroprim

Synonym(s): Ro 11-8958

Class: Diaminopyrimidine

Spectrum of activity:	Gram-positive
Details of activity:	Inhibits dihydrofolic acid reductase and thus, the synthesis of purine. Active against Gram-positive bacteria including trimethoprim-resistant strains.
Description:	Synthetic compound. Trimethoprim derivative
Year first mentioned:	1993
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	CCOC1=CC(=CC(=C1N2C=CC=C2)OCC)CC3=C(N)N=C(N)N=C3
Isomeric SMILES:	CCOC1=CC(=CC(=C1N2C=CC=C2)OCC)CC3=CN=C(N=C3N)N
InChI:	InChI=1S/C19H23N5O2/c1-3-25-15-10-13(9-14-12-22-19(21)23-18(14)20)11-16(26-4-2)17(15)24-7-5-6-8-24/h5-8,10-12H,3-4,9H2,1-2H3,(H4,20,21,22,23)
InChI Key:	NMARPFMJVCXSAV-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/68916

External links:
Guide to Pharmacology:	epiroprim
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163334/
Citation:	https://link.springer.com/article/10.1007/BF00931533