Compound ID | 1968

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Epiroprim

Synonym(s): Ro 11-8958

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Folate synthesis inhibitor. Dihydrofolate reductase inhibitor; DHFR inhibitor
Target Pathogen: Active against Gram-positive bacteria including trimethoprim-resistant strains.
Description: Synthetic compound; trimethoprim derivative; a diaminopyrimidine
Year first mentioned: 1993
Development status: Experimental
Chemical structure(s):
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Molecular weight: 353.42
Iso. SMILES: CCOC1=CC(=CC(=C1N2C=CC=C2)OCC)CC3=CN=C(N=C3N)N
InChI Key: NMARPFMJVCXSAV-UHFFFAOYSA-N
Can. SMILES: CCOC1=CC(=CC(=C1N2C=CC=C2)OCC)CC3=C(N)N=C(N)N=C3
InChI: InChI=1S/C19H23N5O2/c1-3-25-15-10-13(9-14-12-22-19(21)23-18(14)20)11-16(26-4-2)17(15)24-7-5-6-8-24/h5-8,10-12H,3-4,9H2,1-2H3,(H4,20,21,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/68916
Guide to Pharmacology: epiroprim
Citations:
  • https://link.springer.com/article/10.1007/BF00931533
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC163334/

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