Compound ID | 1969

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Tetroxoprim

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Folate synthesis inhibitor. Dihydrofolate reductase inhibitor; DHFR inhibitor
Target Pathogen: Active against many Gram-positive, Gram-negative strains, and protozoal pathogens
Description: Synthetic compound; trimethoprim derivative; oral and parenteral application; a diaminopyrimidine
Year first mentioned: 1979
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 334.37
Iso. SMILES: COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
InChI Key: WSWJIZXMAUYHOE-UHFFFAOYSA-N
Can. SMILES: COCCOC1=C(C=C(CC2=C(N)N=C(N)N=C2)C=C1OC)OC
InChI: InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/65450
Guide to Pharmacology: tetroxoprim
Citations:
  • https://academic.oup.com/jac/article/5/Supplement_B/45/724664
  • https://academic.oup.com/jac/issue/5/Supplement_B
  • https://academic.oup.com/jac/article-abstract/5/Supplement_B/19/724634?redirectedFrom=fulltext

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