Tetroxoprim

Class: Diaminopyrimidine

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits dihydrofolic acid reductase and thus, the synthesis of purine. Active against many Gram-psitive, Gram-negative strains, and protozoal pathogens
Description:	Synthetic compound. Trimethoprim derivative. Oral and parenteral application.
Year first mentioned:	1979
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	COCCOC1=C(C=C(CC2=C(N)N=C(N)N=C2)C=C1OC)OC
Isomeric SMILES:	COCCOC1=C(C=C(C=C1OC)CC2=CN=C(N=C2N)N)OC
InChI:	InChI=1S/C16H22N4O4/c1-21-4-5-24-14-12(22-2)7-10(8-13(14)23-3)6-11-9-19-16(18)20-15(11)17/h7-9H,4-6H2,1-3H3,(H4,17,18,19,20)
InChI Key:	WSWJIZXMAUYHOE-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/65450

External links:
Guide to Pharmacology:	tetroxoprim
Main Source:	https://academic.oup.com/jac/article-abstract/5/Supplement_B/19/724634?redirectedFrom=fulltext
Citations:	https://academic.oup.com/jac/article/5/Supplement_B/45/724664 https://academic.oup.com/jac/issue/5/Supplement_B