Compound ID | 1983

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Nifuroxazide

Class: Nitrofuran

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad mechanism of action by by damaging bacterial DNA. Active against many Enterobacteriaceae and staphylococci.
Description: Synthetic compound. No useful systemic absorbtion, used for diarrhoeae and colitis in humans and animals
Year first mentioned: 1966
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 275.22
Iso. SMILES: C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O
InChI Key: YCWSUKQGVSGXJO-NTUHNPAUSA-N
Can. SMILES: C1=C(C=CC(=C1)O)C(=O)N/N=C/C2=CC=C([N+](=O)[O-])O2
InChI: InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5337997
Guide to Pharmacology: nifuroxazide
Citations:
  • https://www.ema.europa.eu/en/documents/psusa/nifuroxazide-cmdh-scientific-conclusions-grounds-variation-amendments-product-information-timetable/00002160/202108_en.pdf
  • https://www.nature.com/articles/cddis201563
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239654/
  • https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2672.1985.tb01710.x

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