Nifuroxazide

Class: Nitrofuran

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Broad mechanism of action by by damaging bacterial DNA. Active against many Enterobacteriaceae and staphylococci.
Description:	Synthetic compound. No useful systemic absorbtion, used for diarrhoeae and colitis in humans and animals
Year first mentioned:	1966
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)O)C(=O)N/N=C/C2=CC=C([N+](=O)[O-])O2
Isomeric SMILES:	C1=CC(=CC=C1C(=O)N/N=C/C2=CC=C(O2)[N+](=O)[O-])O
InChI:	InChI=1S/C12H9N3O5/c16-9-3-1-8(2-4-9)12(17)14-13-7-10-5-6-11(20-10)15(18)19/h1-7,16H,(H,14,17)/b13-7+
InChI Key:	YCWSUKQGVSGXJO-NTUHNPAUSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5337997

External links:
Guide to Pharmacology:	nifuroxazide
Main Source:	https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2672.1985.tb01710.x
Citations:	https://www.ema.europa.eu/en/documents/psusa/nifuroxazide-cmdh-scientific-conclusions-grounds-variation-amendments-product-information-timetable/00002160/202108_en.pdf https://www.nature.com/articles/cddis201563 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239654/