Compound ID | 1984

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Nifurtimox

Class: Nitrofuran

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Broad mechanism of action by by damaging bacterial DNA
Description: Synthetic compound. Used for protozoal infections (Chagas disease, sleeping sickness)
Year first mentioned: 1965
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 287.29
Iso. SMILES: CC1CS(=O)(=O)CCN1/N=C/C2=CC=C(O2)[N+](=O)[O-]
InChI Key: ARFHIAQFJWUCFH-IZZDOVSWSA-N
Can. SMILES: CC1CS(=O)(=O)CCN1/N=C/C2=CC=C([N+](=O)[O-])O2
InChI: InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/Nifurtimox
Guide to Pharmacology: nifurtimox
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036918/
  • https://www.pnas.org/doi/full/10.1073/pnas.0711014105
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790535/

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