Nifurtimox

Class: Nitrofuran

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Broad mechanism of action by by damaging bacterial DNA
Description:	Synthetic compound. Used for protozoal infections (Chagas disease, sleeping sickness)
Year first mentioned:	1965
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	CC1CS(=O)(=O)CCN1/N=C/C2=CC=C([N+](=O)[O-])O2
Isomeric SMILES:	CC1CS(=O)(=O)CCN1/N=C/C2=CC=C(O2)[N+](=O)[O-]
InChI:	InChI=1S/C10H13N3O5S/c1-8-7-19(16,17)5-4-12(8)11-6-9-2-3-10(18-9)13(14)15/h2-3,6,8H,4-5,7H2,1H3/b11-6+
InChI Key:	ARFHIAQFJWUCFH-IZZDOVSWSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/Nifurtimox

External links:
Guide to Pharmacology:	nifurtimox
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7790535/
Citations:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036918/ https://www.pnas.org/doi/full/10.1073/pnas.0711014105