Florfenicol

Synonym(s): Sch-25298

Class: Phenicol

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to the 23S rRNA of the 50S ribosomal subunit and inhibits the peptidyl transferase activity of the bacterial ribosome, thus preventing protein chain elongation. It is active against Gram-positive and Gram-negative bacteria.
Description:	Synthetic sulfamoyl derivative of chloramphenicol
Year first mentioned:	1981
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O
Isomeric SMILES:	CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O
InChI:	InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
InChI Key:	AYIRNRDRBQJXIF-NXEZZACHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/114811

External links:
Guide to Pharmacology:	florfenicol
Main Source:	https://academic.oup.com/femsre/article/28/5/519/776258