Compound ID | 1990

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Florfenicol

Synonym(s): Sch-25298

Class: Phenicol

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Binds to the 23S rRNA of the 50S ribosomal subunit and inhibits the peptidyl transferase activity of the bacterial ribosome, thus preventing protein chain elongation. It is active against Gram-positive and Gram-negative bacteria.
Description: Synthetic sulfamoyl derivative of chloramphenicol
Year first mentioned: 1981
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 358.21
Iso. SMILES: CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O
InChI Key: AYIRNRDRBQJXIF-NXEZZACHSA-N
Can. SMILES: CS(=O)(=O)C1=CC=C(C=C1)[C@H]([C@@H](CF)NC(=O)C(Cl)Cl)O
InChI: InChI=1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/114811
Guide to Pharmacology: florfenicol
Citation: https://academic.oup.com/femsre/article/28/5/519/776258

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