Pleuromutilin

Synonym(s): Drosophilin B

Class: Pleuromutilin

Spectrum of activity:	Gram-positive
Details of activity:	Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation. It is active against Gram-positive bacteria including MRSA.
Description:	Natural product produced by the fungus Pleurotus
Year first mentioned:	1951
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CO
Isomeric SMILES:	C[C@@H]1CC[C@@]23CCC(=O)[C@H]2[C@@]1([C@@H](C[C@@]([C@H]([C@@H]3C)O)(C)C=C)OC(=O)CO)C
InChI:	InChI=1S/C22H34O5/c1-6-20(4)11-16(27-17(25)12-23)21(5)13(2)7-9-22(14(3)19(20)26)10-8-15(24)18(21)22/h6,13-14,16,18-19,23,26H,1,7-12H2,2-5H3/t13-,14+,16-,18+,19+,20-,21+,22+/m1/s1
InChI Key:	ZRZNJUXESFHSIO-BKUNHTPHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/9886081

External links:
Guide to Pharmacology:	pleuromulin
Main Source:	https://pubmed.ncbi.nlm.nih.gov/20112168/
Citations:	https://academic.oup.com/jac/article/69/8/2022/873861 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5204327/