Rolitetracycline

Class: Tetracycline

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. Wide spectrum including protozoae, e.g. Plasmodium
Description:	Semisynthetic tetracycline derivative. Was used topically.
Year first mentioned:	1958
Development status:	Inactive

Chemical structure(s):
Canonical SMILES:	C[C@]1(C2=CC=CC(=C2C(=C3[C@@H]1C[C@H]4[C@@H](C(=O)C(=C([C@]4(C3=O)O)O)C(=O)NCN5CCCC5)N(C)C)O)O)O
Isomeric SMILES:	C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)NCN5CCCC5)N(C)C)O
InChI:	InChI=1S/C27H33N3O8/c1-26(37)13-7-6-8-16(31)17(13)21(32)18-14(26)11-15-20(29(2)3)22(33)19(24(35)27(15,38)23(18)34)25(36)28-12-30-9-4-5-10-30/h6-8,14-15,20,31-32,35,37-38H,4-5,9-12H2,1-3H3,(H,28,36)/t14-,15-,20-,26+,27-/m0/s1
InChI Key:	IKQRPFTXKQQLJF-IAHYZSEUSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54682938

External links:
Guide to Pharmacology:	rolitetracycline
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5042094/
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2481011/