Clomocycline

Class: Tetracycline

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Inhibits protein synthesis by binding reversibly to the bacterial 30S ribosomal subunit and preventing the aminoacyl tRNA from binding to the A site of the ribosome. Wide spectrum including protozoae, e.g. Plasmodium
Description:	Semisynthetic chlortetracycline derivative.
Year first mentioned:	1966
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C(=CC=C4O)Cl)O)O)O)C(=O)NCO)N(C)C)O
Isomeric SMILES:	C[C@@]1([C@H]2C[C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C(C=CC(=C41)Cl)O)O)O)O)C(=O)NCO)N(C)C)O
InChI:	InChI=1S/C23H25ClN2O9/c1-22(34)8-6-9-16(26(2)3)18(30)14(21(33)25-7-27)20(32)23(9,35)19(31)12(8)17(29)13-11(28)5-4-10(24)15(13)22/h4-5,8-9,16,27-29,32,34-35H,6-7H2,1-3H3,(H,25,33)/t8-,9-,16-,22-,23-/m0/s1
InChI Key:	BXTHDFJCJQJHKD-KMVLDZISSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/54680675

External links:
Guide to Pharmacology:	clomocycline
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1048457/