Compound ID | 2025

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Moxifloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Oral, intravenous and topical application; off-patent
Year first mentioned: 1989
Highest development stage: Approved by FDA in 2001
Development status: Approved
Chemical structure(s):
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Molecular weight: 401.43
Iso. SMILES: COC1=C2C(=CC(=C1N3C[C@@H]4CCCN[C@@H]4C3)F)C(=O)C(=CN2C5CC5)C(=O)O
InChI Key: FABPRXSRWADJSP-MEDUHNTESA-N
Can. SMILES: COC1=C(C(=CC2=C1N(C=C(C2=O)C(=O)O)C3CC3)F)N4C[C@@H]5CCCN[C@@H]5C4
InChI: InChI=1S/C21H24FN3O4/c1-29-20-17-13(19(26)14(21(27)28)9-25(17)12-4-5-12)7-15(22)18(20)24-8-11-3-2-6-23-16(11)10-24/h7,9,11-12,16,23H,2-6,8,10H2,1H3,(H,27,28)/t11-,16+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/152946
Guide to Pharmacology: moxifloxacin
Citations:
  • https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90866/
  • https://www.tandfonline.com/doi/abs/10.1517/14740338.2013.796362?journalCode=ieds20
  • https://pubs.acs.org/doi/10.1021/bi5000564

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