Compound ID | 2026

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Levofloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative, L-isomer of ofloxacin. Oral, intravenous and topical application.
Year first mentioned: 1985
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 361.37
Iso. SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
InChI Key: GSDSWSVVBLHKDQ-JTQLQIEISA-N
Can. SMILES: C[C@H]1COC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)N4CCN(C)CC4
InChI: InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/149096
Guide to Pharmacology: levofloxacin
Citations:
  • https://www.ema.europa.eu/en/medicines/human/referrals/quinolone-fluoroquinolone-containing-medicinal-products
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90866/
  • https://www.tandfonline.com/doi/abs/10.1517/14740338.2013.796362?journalCode=ieds20
  • https://pubs.acs.org/doi/10.1021/bi5000564

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