Compound ID | 2027

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Sitafloxacin

Synonym(s): U-6859a

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description: Synthetic quinoline derivate
Year first mentioned: 1992
Development status: Approved in Japan
Chemical structure(s):
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Molecular weight: 409.81
Iso. SMILES: C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)[C@@H]5C[C@@H]5F)F
InChI Key: PNUZDKCDAWUEGK-CYZMBNFOSA-N
Can. SMILES: C1CC12CN(C[C@H]2N)C3=C(C4=C(C=C3F)C(=O)C(=CN4[C@@H]5C[C@@H]5F)C(=O)O)Cl
InChI: InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/461399
Guide to Pharmacology: sitafloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/10910986/
  • https://link.springer.com/article/10.2165/11207380-000000000-00000

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