Compound ID | 2027

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Sitafloxacin

Synonym(s): U-6859a

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivate
Year first mentioned: 1992
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 409.81
Iso. SMILES: C1CC12CN(C[C@H]2N)C3=C(C=C4C(=C3Cl)N(C=C(C4=O)C(=O)O)[C@@H]5C[C@@H]5F)F
InChI Key: PNUZDKCDAWUEGK-CYZMBNFOSA-N
Can. SMILES: C1CC12CN(C[C@H]2N)C3=C(C4=C(C=C3F)C(=O)C(=CN4[C@@H]5C[C@@H]5F)C(=O)O)Cl
InChI: InChI=1S/C19H18ClF2N3O3/c20-14-15-8(17(26)9(18(27)28)5-25(15)12-4-10(12)21)3-11(22)16(14)24-6-13(23)19(7-24)1-2-19/h3,5,10,12-13H,1-2,4,6-7,23H2,(H,27,28)/t10-,12+,13+/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/461399
Guide to Pharmacology: sitafloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/10910986/
  • https://link.springer.com/article/10.2165/11207380-000000000-00000

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