Compound ID | 2033

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Lomefloxacin

Synonym(s): Maxaquin  |  NY-198

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Mostly topical use
Year first mentioned: 1987
Highest development stage: Approved by FDA in 1992
Development status: Approved
Reason dropped: Discontinued/Withdrawn in US; phototoxicity and central nervous system (CNS) effects
Chemical structure(s):
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Molecular weight: 351.35
Iso. SMILES: CCN1C=C(C(=O)C2=CC(=C(C(=C21)F)N3CCNC(C3)C)F)C(=O)O
InChI Key: ZEKZLJVOYLTDKK-UHFFFAOYSA-N
Can. SMILES: CCN1C=C(C(=O)C2=C1C(=C(C(=C2)F)N3CCNC(C)C3)F)C(=O)O
InChI: InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3948
Guide to Pharmacology: lomefloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/15917145/
  • https://pubmed.ncbi.nlm.nih.gov/24528107/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90866/

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