Compound ID | 2034

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Nadifloxacin

Synonym(s): OPC-7251

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Topical use for skin infections (acne vulgaris).
Year first mentioned: 1989
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 360.38
Iso. SMILES: CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O
InChI Key: JYJTVFIEFKZWCJ-UHFFFAOYSA-N
Can. SMILES: CC1CCC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)N4CCC(CC4)O
InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4410
Guide to Pharmacology: nadifloxacin
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518973/
  • https://www.jle.com/fr/revues/ejd/e-docs/clinical_and_bacteriological_evaluation_of_nadifloxacin_1_cream_in_patients_with_acne_vulgaris_a_double_blind_phase_iii_comp_267557/article.phtml

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