Nadifloxacin

Synonym(s): OPC-7251

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative. Topical use for skin infections (acne vulgaris).
Year first mentioned:	1989
Development status:	Approved in several countries

Chemical structure(s):
Canonical SMILES:	CC1CCC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)N4CCC(CC4)O
Isomeric SMILES:	CC1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O
InChI:	InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
InChI Key:	JYJTVFIEFKZWCJ-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/4410

External links:
Guide to Pharmacology:	nadifloxacin
Main Source:	https://www.jle.com/fr/revues/ejd/e-docs/clinical_and_bacteriological_evaluation_of_nadifloxacin_1_cream_in_patients_with_acne_vulgaris_a_double_blind_phase_iii_comp_267557/article.phtml
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8518973/