Norfloxacin

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative. Oral, intravenous and topical application.
Year first mentioned:	1978
Development status:	Approved, off-patent, mostly available in topical forms

Chemical structure(s):
Canonical SMILES:	CCN1C=C(C(=O)C2=C1C=C(C(=C2)F)N3CCNCC3)C(=O)O
Isomeric SMILES:	CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
InChI:	InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
InChI Key:	OGJPXUAPXNRGGI-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/4539

External links:
Guide to Pharmacology:	norfloxacin
Main Source:	https://www.sciencedirect.com/science/article/pii/S0016508518348911
Citation:	https://pubmed.ncbi.nlm.nih.gov/36265724/