Compound ID | 2036

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Norfloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Oral, intravenous and topical application.
Year first mentioned: 1978
Highest development stage: Approved
Development status: Approved
Reason dropped: Restricted use due to high levels of bacterial resistant and safety concerns
Chemical structure(s):
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Molecular weight: 319.33
Iso. SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
InChI Key: OGJPXUAPXNRGGI-UHFFFAOYSA-N
Can. SMILES: CCN1C=C(C(=O)C2=C1C=C(C(=C2)F)N3CCNCC3)C(=O)O
InChI: InChI=1S/C16H18FN3O3/c1-2-19-9-11(16(22)23)15(21)10-7-12(17)14(8-13(10)19)20-5-3-18-4-6-20/h7-9,18H,2-6H2,1H3,(H,22,23)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4539
Guide to Pharmacology: norfloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/36265724/
  • https://www.sciencedirect.com/science/article/pii/S0016508518348911

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