Ofloxacin

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative; racemic mixture. Oral, intravenous and topical application.
Year first mentioned:	1980
Development status:	Approved, off-patent, not available in many countries

Chemical structure(s):
Canonical SMILES:	CC1COC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)N4CCN(C)CC4
Isomeric SMILES:	CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N4CCN(CC4)C)F)C(=O)O
InChI:	InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChI Key:	GSDSWSVVBLHKDQ-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/4583

External links:
Guide to Pharmacology:	ofloxacin
Main Source:	https://www.sciencedirect.com/science/article/abs/pii/S1341321X02712099
Citations:	https://pubmed.ncbi.nlm.nih.gov/36265724/ https://pubmed.ncbi.nlm.nih.gov/36453351/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399897/