Pazufloxacin

Synonym(s): T-3762

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative. Oral, intravenous and topical application
Year first mentioned:	1986
Development status:	Approved in Japan, off-patent

Chemical structure(s):
Canonical SMILES:	C[C@H]1COC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)C4(CC4)N
Isomeric SMILES:	C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O
InChI:	InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1
InChI Key:	XAGMUUZPGZWTRP-ZETCQYMHSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/65957

External links:
Guide to Pharmacology:	pazufloxacin
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245492/
Citations:	https://pubmed.ncbi.nlm.nih.gov/28923301/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312304/