Compound ID | 2038

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Pazufloxacin

Synonym(s): T-3762

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Oral, intravenous and topical application
Year first mentioned: 1986
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 318.3
Iso. SMILES: C[C@H]1COC2=C3N1C=C(C(=O)C3=CC(=C2C4(CC4)N)F)C(=O)O
InChI Key: XAGMUUZPGZWTRP-ZETCQYMHSA-N
Can. SMILES: C[C@H]1COC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)C4(CC4)N
InChI: InChI=1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/65957
Guide to Pharmacology: pazufloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/28923301/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9312304/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC245492/

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