Compound ID | 2039

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Pefloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative.
Year first mentioned: 1979
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 333.36
Iso. SMILES: CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCN(CC3)C)F)C(=O)O
InChI Key: FHFYDNQZQSQIAI-UHFFFAOYSA-N
Can. SMILES: CCN1C=C(C(=O)C2=C1C=C(C(=C2)F)N3CCN(C)CC3)C(=O)O
InChI: InChI=1S/C17H20FN3O3/c1-3-20-10-12(17(23)24)16(22)11-8-13(18)15(9-14(11)20)21-6-4-19(2)5-7-21/h8-10H,3-7H2,1-2H3,(H,23,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/51081
Guide to Pharmacology: pefloxacin
Citations:
  • https://www.ema.europa.eu/en/news/disabling-potentially-permanent-side-effects-lead-suspension-restrictions-quinolone-fluoroquinolone
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC89784/

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