Compound ID | 2040

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Rufloxacin

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative.
Year first mentioned: 1987
Highest development stage: Approved
Development status: Approved
Reason dropped: Safety concerns
Chemical structure(s):
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Molecular weight: 363.41
Iso. SMILES: CN1CCN(CC1)C2=C(C=C3C4=C2SCCN4C=C(C3=O)C(=O)O)F
InChI Key: NJCJBUHJQLFDSW-UHFFFAOYSA-N
Can. SMILES: CN1CCN(CC1)C2=C3C4=C(C=C2F)C(=O)C(=CN4CCS3)C(=O)O
InChI: InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/Rufloxacin
Guide to Pharmacology: rufloxacin
Citations:
  • https://doi.org/10.1159/000238865
  • https://academic.oup.com/jac/article/31/6/855/707624?login=true
  • https://academic.oup.com/jac/article/29/6/649/681285

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