Rufloxacin

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative.
Year first mentioned:	1987
Highest developmental phase:	Approved
Development status:	Approved, off-patent, not available in most countries

Chemical structure(s):
Canonical SMILES:	CN1CCN(CC1)C2=C3C4=C(C=C2F)C(=O)C(=CN4CCS3)C(=O)O
Isomeric SMILES:	CN1CCN(CC1)C2=C(C=C3C4=C2SCCN4C=C(C3=O)C(=O)O)F
InChI:	InChI=1S/C17H18FN3O3S/c1-19-2-4-20(5-3-19)14-12(18)8-10-13-16(14)25-7-6-21(13)9-11(15(10)22)17(23)24/h8-9H,2-7H2,1H3,(H,23,24)
InChI Key:	NJCJBUHJQLFDSW-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/Rufloxacin

External links:
Guide to Pharmacology:	rufloxacin
Main Source:	https://academic.oup.com/jac/article/29/6/649/681285
Citations:	https://doi.org/10.1159/000238865 https://academic.oup.com/jac/article/31/6/855/707624?login=true