Compound ID | 2042

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Temafloxacin

Synonym(s): A-62254

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative.
Year first mentioned: 1984
Highest development stage: Approved by FDA in 1992
Development status: Withdrawn
Reason dropped: Safety-related withdrawal; severe haemolytic-uremic syndrome
Chemical structure(s):
Click here for structure editor
Molecular weight: 417.38
Iso. SMILES: CC1CN(CCN1)C2=C(C=C3C(=C2)N(C=C(C3=O)C(=O)O)C4=C(C=C(C=C4)F)F)F
InChI Key: QKDHBVNJCZBTMR-UHFFFAOYSA-N
Can. SMILES: CC1CN(CCN1)C2=CC3=C(C=C2F)C(=O)C(=CN3C4=CC=C(C=C4F)F)C(=O)O
InChI: InChI=1S/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/60021
Guide to Pharmacology: temafloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/11549783/
  • https://pubmed.ncbi.nlm.nih.gov/8086558/

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