Rosoxacin

Class: Quinolone

Spectrum of activity:	Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative
Year first mentioned:	1979
Development status:	Approved, withdrawn

Chemical structure(s):
Canonical SMILES:	CCN1C=C(C(=O)C2=CC=C(C=C21)C3=CC=NC=C3)C(=O)O
Isomeric SMILES:	CCN1C=C(C(=O)C2=C1C=C(C=C2)C3=CC=NC=C3)C(=O)O
InChI:	InChI=1S/C17H14N2O3/c1-2-19-10-14(17(21)22)16(20)13-4-3-12(9-15(13)19)11-5-7-18-8-6-11/h3-10H,2H2,1H3,(H,21,22)
InChI Key:	XBPZXDSZHPDXQU-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/287180

External links:
Guide to Pharmacology:	rosoxacin
Main Source:	https://pubmed.ncbi.nlm.nih.gov/1663996/