Compound ID | 2045

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Piromidic acid

Class: Quinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic pyridopyrimidine derivative, closely related to oxolinic acid and nalidixic acid
Year first mentioned: 1967
Highest development stage: Approved
Development status: Approved
Chemical structure(s):
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Molecular weight: 288.3
Iso. SMILES: CCN1C=C(C(=O)C2=CN=C(N=C21)N3CCCC3)C(=O)O
InChI Key: RCIMBBZXSXFZBV-UHFFFAOYSA-N
Can. SMILES: CCN1C=C(C(=O)C2=C1N=C(N=C2)N3CCCC3)C(=O)O
InChI: InChI=1S/C14H16N4O3/c1-2-17-8-10(13(20)21)11(19)9-7-15-14(16-12(9)17)18-5-3-4-6-18/h7-8H,2-6H2,1H3,(H,20,21)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/4855
Guide to Pharmacology: piromidic acid
Citation: https://academic.oup.com/jambio/article-abstract/44/2/191/6729064?redirectedFrom=fulltext

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