Compound ID | 2046

Update compound information

Fleroxacin

Synonym(s): Ro-23-6240  |  Megalocin  |  AM-833

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative.
Year first mentioned: 1986
Highest development stage: Approved, off-patent, withdrawn in most countries
Development status: Withdrawn
Reason dropped: Phototoxicity
Chemical structure(s):
Click here for structure editor
Molecular weight: 369.34
Iso. SMILES: CN1CCN(CC1)C2=C(C=C3C(=C2F)N(C=C(C3=O)C(=O)O)CCF)F
InChI Key: XBJBPGROQZJDOJ-UHFFFAOYSA-N
Can. SMILES: CN1CCN(CC1)C2=C(C3=C(C=C2F)C(=O)C(=CN3CCF)C(=O)O)F
InChI: InChI=1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3357
Guide to Pharmacology: fleroxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/15917145/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399897/
  • https://pubmed.ncbi.nlm.nih.gov/11354912/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.