Compound ID | 2048

Update compound information

Finafloxacin

Synonym(s): BAY35-3377

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Topical use, othic administration.
Year first mentioned: 2000
Highest development stage: Approved by FDA in 2014
Development status: Approved
Chemical structure(s):
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Molecular weight: 398.39
Iso. SMILES: C1CC1N2C=C(C(=O)C3=CC(=C(C(=C32)C#N)N4C[C@H]5[C@H](C4)OCCN5)F)C(=O)O
InChI Key: FYMHQCNFKNMJAV-HOTGVXAUSA-N
Can. SMILES: C1CC1N2C=C(C(=O)C3=C2C(=C(C(=C3)F)N4C[C@H]5[C@H](C4)OCCN5)C#N)C(=O)O
InChI: InChI=1S/C20H19FN4O4/c21-14-5-11-17(25(10-1-2-10)7-13(19(11)26)20(27)28)12(6-22)18(14)24-8-15-16(9-24)29-4-3-23-15/h5,7,10,15-16,23H,1-4,8-9H2,(H,27,28)/t15-,16-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/11567473
Guide to Pharmacology: finafloxacin
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399897/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878067/

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