Compound ID | 2049

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Tosufloxacin

Synonym(s): T-3262

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic 1,8-naphthyridine derivative
Year first mentioned: 1985
Highest development stage: Approved
Development status: Approved
Reason dropped: Severe thrombocytopenia, nephritis, hepatotoxicity
Chemical structure(s):
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Molecular weight: 404.34
Iso. SMILES: C1CN(CC1N)C2=C(C=C3C(=O)C(=CN(C3=N2)C4=C(C=C(C=C4)F)F)C(=O)O)F
InChI Key: WUWFMDMBOJLQIV-UHFFFAOYSA-N
Can. SMILES: C1=C(C=C(C(=C1)N2C=C(C(=O)C3=C2N=C(C(=C3)F)N4CCC(C4)N)C(=O)O)F)F
InChI: InChI=1S/C19H15F3N4O3/c20-9-1-2-15(13(21)5-9)26-8-12(19(28)29)16(27)11-6-14(22)18(24-17(11)26)25-4-3-10(23)7-25/h1-2,5-6,8,10H,3-4,7,23H2,(H,28,29)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5517
Guide to Pharmacology: tosufloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/11549783/
  • https://pubmed.ncbi.nlm.nih.gov/3182417/

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