Besifloxacin

Synonym(s): BOL-303224-A

Class: Fluoroquinolone

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description:	Synthetic quinoline derivative. Topical use, ophthalmic administration
Year first mentioned:	2000
Development status:	Approved

Chemical structure(s):
Canonical SMILES:	C1CCN(C[C@@H](C1)N)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)Cl
Isomeric SMILES:	C1CCN(C[C@@H](C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI:	InChI=1S/C19H21ClFN3O3/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23/h7,9-11H,1-6,8,22H2,(H,26,27)/t10-/m1/s1
InChI Key:	QFFGVLORLPOAEC-SNVBAGLBSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/10178705

External links:
Guide to Pharmacology:	besifloxacin
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399897/
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609799/