Compound ID | 2050

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Besifloxacin

Synonym(s): BOL-303224-A

Class: Fluoroquinolone

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: DNA synthesis inhibitor. Binds to type II topoisomerases, gyrase and topoisomerase IV to inhibitor DNA cleavage and ligation reactions; bacterial topoisomerase inhibitor
Description: Synthetic quinoline derivative. Topical use, ophthalmic administration
Year first mentioned: 2000
Highest development stage: Approved by FDA in 2009
Development status: Approved
Chemical structure(s):
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Molecular weight: 393.84
Iso. SMILES: C1CCN(C[C@@H](C1)N)C2=C(C=C3C(=C2Cl)N(C=C(C3=O)C(=O)O)C4CC4)F
InChI Key: QFFGVLORLPOAEC-SNVBAGLBSA-N
Can. SMILES: C1CCN(C[C@@H](C1)N)C2=C(C3=C(C=C2F)C(=O)C(=CN3C4CC4)C(=O)O)Cl
InChI: InChI=1S/C19H21ClFN3O3/c20-15-16-12(18(25)13(19(26)27)9-24(16)11-4-5-11)7-14(21)17(15)23-6-2-1-3-10(22)8-23/h7,9-11H,1-6,8,22H2,(H,26,27)/t10-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/10178705
Guide to Pharmacology: besifloxacin
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9609799/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8399897/

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