Compound ID | 2051

Update compound information

Levonadifloxacin

Synonym(s): WCK 771  |  WCK-771  |  WCK771

Class: Fluoroquinolone

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Binds to type II topoisomerases, gyrase and topoisomerase IV and thus, inhibits DNA cleavage and ligation reactions. It kills bacterial cells by increasing the concentration of enzyme–DNA cleavage complexes, thereby inhibiting cell replication.
Description: Synthetic quinoline derivative. Isomer of nadifloxacin. Prodrug alalevonadifloxacin (WCK2349) for oral administration. Use in skin and soft tissue infections and other staphylococcal infections.
Institute where first reported: Wockhardt, India
Year first mentioned: 2001
Highest developmental phase: Approved 2014
Development status: Approved
Chemical structure(s):
Click here for structure editor
Molecular weight: 360.38
Iso. SMILES: C[C@H]1CCC2=C3N1C=C(C(=O)C3=CC(=C2N4CCC(CC4)O)F)C(=O)O
InChI Key: JYJTVFIEFKZWCJ-JTQLQIEISA-N
Can. SMILES: C[C@H]1CCC2=C(C(=CC3=C2N1C=C(C3=O)C(=O)O)F)N4CCC(CC4)O
InChI: InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)/t10-/m0/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/9850038
Guide to Pharmacology: levonadifloxacin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/33025952/
  • https://pubmed.ncbi.nlm.nih.gov/35146781/
  • https://pubmed.ncbi.nlm.nih.gov/33307757/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.