Compound ID | 2055

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Dalfopristin

Synonym(s): Pristinamycin IIA

Class: Streptogramin

Spectrum of activity: Gram-positive
Details of activity: Binds to the bacterial 50S ribosomal subunit and inhibits the elongation process of protein synthesis
Description: Component of the combination product quinupristin/dalfopristin
Year first mentioned: 1989
Development status: Approved, off-patent, discontinued in most countries
Chemical structure(s):
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Molecular weight: 690.85
Iso. SMILES: CCN(CC)CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@@H]([C@@H](/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC3=NC(=CO3)C2=O)O)/C)C)C(C)C
InChI Key: SUYRLXYYZQTJHF-VMBLUXKRSA-N
Can. SMILES: CCN(CC)CCS(=O)(=O)[C@@H]1CCN2[C@H]1C(=O)O[C@H](C(C)C)[C@H](C)/C=C/C(=O)NC/C=C/C(=C/[C@H](CC(=O)CC3=NC(=CO3)C2=O)O)/C
InChI: InChI=1S/C34H50N4O9S/c1-7-37(8-2)16-17-48(44,45)28-13-15-38-31(28)34(43)47-32(22(3)4)24(6)11-12-29(41)35-14-9-10-23(5)18-25(39)19-26(40)20-30-36-27(21-46-30)33(38)42/h9-12,18,21-22,24-25,28,31-32,39H,7-8,13-17,19-20H2,1-6H3,(H,35,41)/b10-9+,12-11+,23-18+/t24-,25-,28-,31-,32-/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6323289
Guide to Pharmacology: dalfopristin
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/3096930/
  • https://pubmed.ncbi.nlm.nih.gov/1399955/

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