Sulfabenzamide

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative
Year first mentioned:	1943
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	C1=CC=C(C=C1)C(=O)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C13H12N2O3S/c14-11-6-8-12(9-7-11)19(17,18)15-13(16)10-4-2-1-3-5-10/h1-9H,14H2,(H,15,16)
InChI Key:	PBCZLFBEBARBBI-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/Sulfabenzamide

External links:
Guide to Pharmacology:	sulfabenzamide
Main Source:	https://pubs.acs.org/doi/pdf/10.1021/ja01251a029