Compound ID | 206

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MAC-0170636

Class: Cell-wall synthesis inhibitor

Spectrum of activity: Gram-positive
Details of activity: Bacillus subtilis cell wall inhibition (UppS inhibitor)
Institute where first reported: Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
Year first mentioned: 2014
Highest developmental phase: Preclinical
Development status: Active
Chemical structure(s):
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Molecular weight: 453.33
Iso. SMILES: CC(=O)NC1=CC=C(C=C1)N=CC2=CC(=C(C(=C2)Br)OCC3=CC=CC=C3)OC
InChI Key: SKSULVXTJVWJHF-UHFFFAOYSA-N
Can. SMILES: CC(=O)NC1=CC=C(C=C1)N=CC2=CC(=C(C(=C2)Br)OCC3=CC=CC=C3)OC
InChI: InChI=1S/C23H21BrN2O3/c1-16(27)26-20-10-8-19(9-11-20)25-14-18-12-21(24)23(22(13-18)28-2)29-15-17-6-4-3-5-7-17/h3-14H,15H2,1-2H3,(H,26,27)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/1049572
Citations:
  • http://aac.asm.org/content/58/6/3261.full
  • https://journals.asm.org/doi/full/10.1128/aac.02352-14

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