Compound ID | 2060

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Sulfacetamide

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative. Various topical and ophthalmic preparations.
Year first mentioned: 1941
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 214.24
Iso. SMILES: CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N
InChI Key: SKIVFJLNDNKQPD-UHFFFAOYSA-N
Can. SMILES: CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N
InChI: InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5320
Guide to Pharmacology: sulfacetamide
Citation: https://pubmed.ncbi.nlm.nih.gov/13476879/

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