Sulfacetamide

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative. Various topical and ophthalmic preparations.
Year first mentioned:	1941
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N
Isomeric SMILES:	CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N
InChI:	InChI=1S/C8H10N2O3S/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8/h2-5H,9H2,1H3,(H,10,11)
InChI Key:	SKIVFJLNDNKQPD-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5320

External links:
Guide to Pharmacology:	sulfacetamide
Main Source:	https://pubmed.ncbi.nlm.nih.gov/13476879/