Compound ID | 2061

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Sulfachlorpyridazine

Synonym(s): Sulfachloropyridazine

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative.
Year first mentioned: 1957
Development status: Discontinued
Chemical structure(s):
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Molecular weight: 284.72
Iso. SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl
InChI Key: XOXHILFPRYWFOD-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)S(=O)(=O)NC2=CC=C(Cl)N=N2)N
InChI: InChI=1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/6634
Guide to Pharmacology: sulfachlorpyridazine
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/32417517/
  • https://pubmed.ncbi.nlm.nih.gov/33121774/
  • https://pubmed.ncbi.nlm.nih.gov/13488280/

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