Sulfachlorpyridazine

Synonym(s): Sulfachloropyridazine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative.
Year first mentioned:	1957
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)S(=O)(=O)NC2=CC=C(Cl)N=N2)N
Isomeric SMILES:	C1=CC(=CC=C1N)S(=O)(=O)NC2=NN=C(C=C2)Cl
InChI:	InChI=1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
InChI Key:	XOXHILFPRYWFOD-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/6634

External links:
Guide to Pharmacology:	sulfachlorpyridazine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/13488280/
Citations:	https://pubmed.ncbi.nlm.nih.gov/32417517/ https://pubmed.ncbi.nlm.nih.gov/33121774/