Sulfadiazine

Synonym(s): Silver sulfadiazine (salt of sulphadiazine)

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance. Silver sulfadizine is water insoluble and acts as a combination of silver and sulfadizine.
Description:	Synthetic sufanilamide derivative; intermediate-acting (8-12 hours). Oral and topical use (silver sulfadiazine, especially for infected burns).
Year first mentioned:	1941
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
InChI Key:	SEEPANYCNGTZFQ-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5215

External links:
Guide to Pharmacology:	sulfadiazine
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601063/pdf/yjbm00510-0025.pdf
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889/