Sulfadimethoxine

Synonym(s): Sulfadimethoxydiazine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; intermediate-acting (8-12 hours).
Year first mentioned:	1958
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	COC1=CC(=NC(=N1)OC)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
InChI:	InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI Key:	ZZORFUFYDOWNEF-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5323

External links:
Guide to Pharmacology:	sulfadimethoxine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/14446486/
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889/