Compound ID | 2063

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Sulfadimethoxine

Synonym(s): Sulfadimethoxydiazine

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative; intermediate-acting (8-12 hours).
Year first mentioned: 1958
Development status: Discontinued
Chemical structure(s):
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Molecular weight: 310.33
Iso. SMILES: COC1=NC(=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
InChI Key: ZZORFUFYDOWNEF-UHFFFAOYSA-N
Can. SMILES: COC1=CC(=NC(=N1)OC)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C12H14N4O4S/c1-19-11-7-10(14-12(15-11)20-2)16-21(17,18)9-5-3-8(13)4-6-9/h3-7H,13H2,1-2H3,(H,14,15,16)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5323
Guide to Pharmacology: sulfadimethoxine
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889/
  • https://pubmed.ncbi.nlm.nih.gov/14446486/

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