Sulfaguanidine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative
Year first mentioned:	1941
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)S(=O)(=O)N=C(N)N)N
Isomeric SMILES:	C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N
InChI:	InChI=1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
InChI Key:	BRBKOPJOKNSWSG-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5324

External links:
Guide to Pharmacology:	sulfaguanidine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/14902794/
Citation:	https://pubmed.ncbi.nlm.nih.gov/36265615/