Compound ID | 2064

Update compound information

Sulfaguanidine

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative
Year first mentioned: 1941
Development status: Discontinued
Chemical structure(s):
Click here for structure editor
Molecular weight: 214.25
Iso. SMILES: C1=CC(=CC=C1N)S(=O)(=O)N=C(N)N
InChI Key: BRBKOPJOKNSWSG-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)S(=O)(=O)N=C(N)N)N
InChI: InChI=1S/C7H10N4O2S/c8-5-1-3-6(4-2-5)14(12,13)11-7(9)10/h1-4H,8H2,(H4,9,10,11)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5324
Guide to Pharmacology: sulfaguanidine
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/36265615/
  • https://pubmed.ncbi.nlm.nih.gov/14902794/

    • AntibioticDB is supported by GARDP.

    If you have feedback, experience problems, or are interested in a collaboration, please contact us. | Terms and conditions

    The content of this site is intended for educational and scientific research purposes only and not as a source of medical advice or consultation.