Compound ID | 2065

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Sulfamerazine

Synonym(s): Sulfamethyldiazine

Class: Sulfonamide

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Folate synthesis inhibitor. Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid; dihydropteroate synthase inhibitor (DHPS inhibitor)
Description: Synthetic sufanilamide derivative
Year first mentioned: 1944
Highest development stage: Approved
Development status: Withdrawn
Chemical structure(s):
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Molecular weight: 264.31
Iso. SMILES: CC1=NC(=NC=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI Key: QPPBRPIAZZHUNT-UHFFFAOYSA-N
Can. SMILES: CC1=CC=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H12N4O2S/c1-8-6-7-13-11(14-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/5325
Guide to Pharmacology: sulfamerazine
Citations:
  • https://www.sciencedirect.com/science/article/pii/S0147651322008193?via%3Dihub
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2038406/

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