Sulfamethazine

Synonym(s): Sulfadimidine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative. Used commonly in veterinary medicine and as growth promotor.
Year first mentioned:	1945
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	CC1=NC(=NC(=C1)C)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	CC1=CC(=NC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)C
InChI:	InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI Key:	ASWVTGNCAZCNNR-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5327

External links:
Guide to Pharmacology:	sulfadimidine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/13683221/
Citations:	https://pubmed.ncbi.nlm.nih.gov/10620471/ https://pubmed.ncbi.nlm.nih.gov/36522071/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8046889/