Sulfamethizole

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; short-acting (4-8 hours). Oral application.
Year first mentioned:	1953
Development status:	Approved, off-patent, discontinued in most countries

Chemical structure(s):
Canonical SMILES:	CC1=NN=C(NS(=O)(=O)C2=CC=C(C=C2)N)S1
Isomeric SMILES:	CC1=NN=C(S1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)
InChI Key:	VACCAVUAMIDAGB-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/Sulfamethizole

External links:
Guide to Pharmacology:	sulfamethizole
Main Source:	https://pubmed.ncbi.nlm.nih.gov/14425767/
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797026/