Sulfapyridine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; short-acting (4-8 hours); metabolite of sulfasalazine.
Year first mentioned:	1937
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=CC(=NC=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C11H11N3O2S/c12-9-4-6-10(7-5-9)17(15,16)14-11-3-1-2-8-13-11/h1-8H,12H2,(H,13,14)
InChI Key:	GECHUMIMRBOMGK-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5336

External links:
Guide to Pharmacology:	sulfapyridine
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601063/pdf/yjbm00510-0025.pdf
Citation:	https://pubmed.ncbi.nlm.nih.gov/3042521/