Sulfathiazole

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; short-acting (4-8 hours). Oral and topical application.
Year first mentioned:	1942
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)S(=O)(=O)NC2=NC=CS2)N
Isomeric SMILES:	C1=CC(=CC=C1N)S(=O)(=O)NC2=NC=CS2
InChI:	InChI=1S/C9H9N3O2S2/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9/h1-6H,10H2,(H,11,12)
InChI Key:	JNMRHUJNCSQMMB-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/5340

External links:
Guide to Pharmacology:	sulfathiazole
Main Source:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2601063/pdf/yjbm00510-0025.pdf
Citation:	https://pubmed.ncbi.nlm.nih.gov/25455640/