Compound ID | 2076

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Sulfametomidine

Synonym(s): Sulfamethomidine

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative; long-acting (~7 days).
Year first mentioned: 1961
Development status: Discontinued
Chemical structure(s):
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Molecular weight: 294.33
Iso. SMILES: CC1=NC(=CC(=N1)OC)NS(=O)(=O)C2=CC=C(C=C2)N
InChI Key: QKLSCPPJEVXONT-UHFFFAOYSA-N
Can. SMILES: CC1=NC(=CC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
InChI: InChI=1S/C12H14N4O3S/c1-8-14-11(7-12(15-8)19-2)16-20(17,18)10-5-3-9(13)4-6-10/h3-7H,13H2,1-2H3,(H,14,15,16)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/19596
Guide to Pharmacology: sulfametomidine
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/1749708/
  • https://pubmed.ncbi.nlm.nih.gov/1749708/

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