Sulfametomidine

Synonym(s): Sulfamethomidine

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; long-acting (~7 days).
Year first mentioned:	1961
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	CC1=NC(=CC(=N1)NS(=O)(=O)C2=CC=C(C=C2)N)OC
Isomeric SMILES:	CC1=NC(=CC(=N1)OC)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C12H14N4O3S/c1-8-14-11(7-12(15-8)19-2)16-20(17,18)10-5-3-9(13)4-6-10/h3-7H,13H2,1-2H3,(H,14,15,16)
InChI Key:	QKLSCPPJEVXONT-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/19596

External links:
Guide to Pharmacology:	sulfametomidine
Main Source:	https://pubmed.ncbi.nlm.nih.gov/1749708/
Citation:	https://pubmed.ncbi.nlm.nih.gov/1749708/