Compound ID | 2077
Synonym(s): Sulfalene | Sulfamethopyrazine
Class: Sulfa drug / Sulphonamide
Spectrum of activity: | Gram-positive & Gram-negative |
Details of activity: | Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance. |
Description: | Synthetic sufanilamide derivative; long-acting (~7 days). Used in combination for protozoal infections. |
Year first mentioned: | 1953 |
Development status: | Discontinued in most countries |
Chemical structure(s): | |||||||||||
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External links: | |
PubChem link: | https://pubchem.ncbi.nlm.nih.gov/compound/9047 |
Guide to Pharmacology: | sulfalene |
Citations: |
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