Compound ID | 2077
Synonym(s): Sulfalene | Sulfamethopyrazine
Class: Antibacterial sulfonamide (sulfa drug)
Spectrum of activity: | Gram-positive & Gram-negative |
Details of activity: | Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance. |
Description: | Synthetic sufanilamide derivative; long-acting (~7 days). Used in combination for protozoal infections. |
Year first mentioned: | 1953 |
Development status: | Discontinued in most countries |
Chemical structure(s): | |
Canonical SMILES: | COC1=C(N=CC=N1)NS(=O)(=O)C2=CC=C(C=C2)N |
Isomeric SMILES: | COC1=NC=CN=C1NS(=O)(=O)C2=CC=C(C=C2)N |
InChI: | InChI=1S/C11H12N4O3S/c1-18-11-10(13-6-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) |
InChI Key: | KXRZBTAEDBELFD-UHFFFAOYSA-N |
Structure link: | https://pubchem.ncbi.nlm.nih.gov/compound/9047 |
External links: | |
Main Source: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3024282/ |
Citation: | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0006732 |