Sulfametrole

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; intermediate-acting (8-12 hours). Used in combination with trimethoprim.
Year first mentioned:	1975
Development status:	Discontinued in most countries

Chemical structure(s):
Canonical SMILES:	COC1=NSN=C1NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	COC1=NSN=C1NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C9H10N4O3S2/c1-16-9-8(11-17-12-9)13-18(14,15)7-4-2-6(10)3-5-7/h2-5H,10H2,1H3,(H,11,13)
InChI Key:	IZOYMGQQVNAMHS-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/64939

External links:
Guide to Pharmacology:	sulfametrole
Main Source:	https://pubmed.ncbi.nlm.nih.gov/1220516/
Citations:	https://academic.oup.com/jac/article/69/4/1050/702827 https://pubmed.ncbi.nlm.nih.gov/24257317/