Sulfaperine

Synonym(s): Sulfaperin

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative; long-acting (~7 days).
Year first mentioned:	1946
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	CC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
Isomeric SMILES:	CC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI:	InChI=1S/C11H12N4O2S/c1-8-6-13-11(14-7-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
InChI Key:	DZQVFHSCSRACSX-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/68933

External links:
Guide to Pharmacology:	sulfaperin
Main Source:	https://pubmed.ncbi.nlm.nih.gov/7447603/