Compound ID | 2080

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Sulfaperine

Synonym(s): Sulfaperin

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative; long-acting (~7 days).
Year first mentioned: 1946
Development status: Discontinued
Chemical structure(s):
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Molecular weight: 264.31
Iso. SMILES: CC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI Key: DZQVFHSCSRACSX-UHFFFAOYSA-N
Can. SMILES: CC1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N
InChI: InChI=1S/C11H12N4O2S/c1-8-6-13-11(14-7-8)15-18(16,17)10-4-2-9(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/68933
Guide to Pharmacology: sulfaperin
Citation: https://pubmed.ncbi.nlm.nih.gov/7447603/

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