Sulfathiourea

Synonym(s): Sulfathiocarbamide

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative.
Year first mentioned:	1946
Development status:	Discontinued

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)S(=O)(=O)NC(=S)N)N
Isomeric SMILES:	C1=CC(=CC=C1N)S(=O)(=O)NC(=S)N
InChI:	InChI=1S/C7H9N3O2S2/c8-5-1-3-6(4-2-5)14(11,12)10-7(9)13/h1-4H,8H2,(H3,9,10,13)
InChI Key:	UEMLYRZWLVXWRU-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/3000579

External links:
Guide to Pharmacology:	sulfathiourea
Main Source:	https://pubmed.ncbi.nlm.nih.gov/21024878/
Citation:	https://pubmed.ncbi.nlm.nih.gov/2490761/