Compound ID | 2083

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Sulfathiourea

Synonym(s): Sulfathiocarbamide

Class: Sulfonamide

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive & Gram-negative
Mechanism of action: Folate synthesis inhibitor. Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid; dihydropteroate synthase inhibitor (DHPS inhibitor)
Description: Synthetic sufanilamide derivative.
Year first mentioned: 1946
Development status: Withdrawn
Chemical structure(s):
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Molecular weight: 231.3
Iso. SMILES: C1=CC(=CC=C1N)S(=O)(=O)NC(=S)N
InChI Key: UEMLYRZWLVXWRU-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)S(=O)(=O)NC(=S)N)N
InChI: InChI=1S/C7H9N3O2S2/c8-5-1-3-6(4-2-5)14(11,12)10-7(9)13/h1-4H,8H2,(H3,9,10,13)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3000579
Guide to Pharmacology: sulfathiourea
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/2490761/
  • https://pubmed.ncbi.nlm.nih.gov/21024878/

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