Mafenide

Synonym(s): Marfanil  |  sulfamylon  |  ambamide  |  Homosulfanilamide

Class: Antibacterial sulfonamide (sulfa drug)

Spectrum of activity:	Gram-positive  &  Gram-negative
Details of activity:	Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description:	Synthetic sufanilamide derivative: Topical use in burn infections.
Year first mentioned:	1948
Development status:	Approved, off-patent

Chemical structure(s):
Canonical SMILES:	C1=C(C=CC(=C1)S(=O)(=O)N)CN
Isomeric SMILES:	C1=CC(=CC=C1CN)S(=O)(=O)N
InChI:	InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
InChI Key:	TYMRLRRVMHJFTF-UHFFFAOYSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/3998

External links:
Guide to Pharmacology:	mafenide
Main Source:	https://pubmed.ncbi.nlm.nih.gov/5576444/
Citation:	https://pubmed.ncbi.nlm.nih.gov/35143154/