Compound ID | 2084

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Mafenide

Synonym(s): Marfanil  |  sulfamylon  |  ambamide  |  Homosulfanilamide

Class: Sulfa drug / Sulphonamide

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Sulphonamides are structural analogues of p-aminobenzoic acid and act as competitive inhibitors (and alternate substrates) of dihydropteroate synthase (DHPS) to block the synthesis of folic acid. Primarily bacteriostatic; rapid emergence of resistance.
Description: Synthetic sufanilamide derivative: Topical use in burn infections.
Year first mentioned: 1948
Development status: Approved, off-patent
Chemical structure(s):
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Molecular weight: 186.23
Iso. SMILES: C1=CC(=CC=C1CN)S(=O)(=O)N
InChI Key: TYMRLRRVMHJFTF-UHFFFAOYSA-N
Can. SMILES: C1=C(C=CC(=C1)S(=O)(=O)N)CN
InChI: InChI=1S/C7H10N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,5,8H2,(H2,9,10,11)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/3998
Guide to Pharmacology: mafenide
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/35143154/
  • https://pubmed.ncbi.nlm.nih.gov/5576444/

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