Compound ID | 2088

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Aureothricin

Class: RNA polymerase inhibitor (dithiolopyrrolone)

Spectrum of activity: Gram-positive  &  Gram-negative
Details of activity: Inhibits bacterial DNA-dependent RNA polymerase, thus inhibiting bacterial RNA synthesis
Description: Natural product produced by several species of Streptomyces, Saccharothrix and Gram-negative bacteria; co-produced by Streptomyces and functionally related to thiolutin; related to Pseudomonic acid A (mupirocin).
Year first mentioned: 1948
Development status: Experimental
Reason Dropped: Toxic
Chemical structure(s):
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Molecular weight: 242.32
Iso. SMILES: CCC(=O)NC1=C2C(=CSS2)N(C1=O)C
InChI Key: UGZYFXMSMFMTSM-UHFFFAOYSA-N
Can. SMILES: CCC(=O)NC1=C2C(=CSS2)N(C)C1=O
InChI: InChI=1S/C9H10N2O2S2/c1-3-6(12)10-7-8-5(4-14-15-8)11(2)9(7)13/h4H,3H2,1-2H3,(H,10,12)
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/68460
Citations:
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3826145/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132845/
  • https://www.jstage.jst.go.jp/article/yoken1948/1/6/1_6_512/_article/-char/ja/

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