Compound ID | 209

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MAC-0177727

Class: Small molecule antibacterial agent

Agent Type: Synthetic; Small molecule; Direct acting;
Spectrum of activity: Gram-positive
Mechanism of action: Cell wall synthesis inhibitor. Detected by cell wall inhibitor reporter system; shows weak whole cell activity
Description: Synthetic compound from Chembridge and Maybridge Chemicals compound collection
Institute where first reported: Department of Biochemistry and Biomedical Sciences and Michael G. DeGroote Institute of Infectious Disease Research, McMaster University, Hamilton, Ontario, Canada
Year first mentioned: 2014
Development status: Experimental
Chemical structure(s):
Click here for structure editor
Molecular weight: 480.87
Iso. SMILES: COC1=C(C(=CC(=C1)C=C2C(=O)NC(=O)N(C2=O)C3=CC=CC=C3F)Cl)OCC4=CC=CC=C4
InChI Key: CCXKYEFMTVQTDH-UHFFFAOYSA-N
Can. SMILES: COC1=C(C(=CC(=C1)C=C2C(=O)NC(=O)N(C3=C(C=CC=C3)F)C2=O)Cl)OCC4=CC=CC=C4
InChI: InChI=1S/C25H18ClFN2O5/c1-33-21-13-16(12-18(26)22(21)34-14-15-7-3-2-4-8-15)11-17-23(30)28-25(32)29(24(17)31)20-10-6-5-9-19(20)27/h2-13H,14H2,1H3,(H,28,30,32)
External links:
Structure link: https://pubchem.ncbi.nlm.nih.gov/compound/1338808
Citations:
  • http://aac.asm.org/content/58/6/3261.full
  • https://journals.asm.org/doi/full/10.1128/aac.02352-14

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