Compound ID | 2091

Update compound information

Ripostatin

Class: RNA polymerase inhibitor

Spectrum of activity: Gram-positive
Details of activity: Inhibits transcription by binding to the switch region of the bacterial RNA polymerase. The binding site is identical in myxopyronin and corallopyronin but different from the rifamycins.
Description: Natural product produced by myxobacteria; 14-membered macrolide, polyene macrolactone; total synthesis and several analogues
Year first mentioned: 1995
Development status: Experimental
Chemical structure(s):
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Molecular weight: 494.62
Iso. SMILES: C/C/1=C/C/C=C\C/C(=C\C(=O)O[C@@H]2C[C@@H](C1)O[C@](C2)(CC/C(=C/CC3=CC=CC=C3)/C)O)/CC(=O)O
InChI Key: ROPGADFKOUALIE-DJIBYVLHSA-N
Can. SMILES: C/C(=C\CC1=CC=CC=C1)/CC[C@]2(C[C@H]3C[C@@H](C/C(=C\C/C=C\C/C(=C\C(=O)O3)/CC(=O)O)/C)O2)O
InChI: InChI=1S/C30H38O6/c1-22(13-14-24-10-6-4-7-11-24)15-16-30(34)21-27-20-26(36-30)17-23(2)9-5-3-8-12-25(18-28(31)32)19-29(33)35-27/h3-4,6-11,13,19,26-27,34H,5,12,14-18,20-21H2,1-2H3,(H,31,32)/b8-3-,22-13+,23-9-,25-19+/t26-,27-,30+/m1/s1
External links:
PubChem link: https://pubchem.ncbi.nlm.nih.gov/compound/101682974
Citations:
  • https://pubmed.ncbi.nlm.nih.gov/22917024/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2580802/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196380/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC101622/

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