Tiamulin

Synonym(s): Thiamutilin

Class: Pleuromutilin

Spectrum of activity:	Gram-positive
Details of activity:	Binds to the peptidyl transferase component of the 50S subunit of ribosomes, thus inhibiting peptide bond formation. Active against Gram-positive bacteria.
Description:	Semisynthetic pleuromutilin derivative. Used in veterinary medicine
Year first mentioned:	1951
Development status:	Approved for veterinary use off-patent

Chemical structure(s):
Canonical SMILES:	C=C[C@]1(C)C[C@H]([C@]2(C)[C@H](C)CC[C@]3(CCC(=O)[C@@H]23)[C@@H](C)[C@@H]1O)OC(=O)CSCCN(CC)CC
Isomeric SMILES:	CCN(CC)CCSCC(=O)O[C@@H]1C[C@@]([C@H]([C@@H]([C@@]23CC[C@H]([C@@]1([C@@H]2C(=O)CC3)C)C)C)O)(C)C=C
InChI:	InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1
InChI Key:	UURAUHCOJAIIRQ-QGLSALSOSA-N
Structure link:	https://pubchem.ncbi.nlm.nih.gov/compound/656958

External links:
Main Source:	https://academic.oup.com/jac/article/69/8/2022/873861
Citation:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1426994/